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Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model
Joint Authors
Sjøgaard, Gisela
Barbe, Mary F.
Frandsen, U.
Hadrevi, J.
Ørtenblad, N.
Boyle, E.
Lazar, S.
Søgaard, Karen
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Introduction.
Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity.
Method.
A well-established rat model of high repetition high force (HRHF) work was used to investigate if such exposure leads to an increase in cytosolic Ca2+ concentration ([Ca2+]i) and changes in sarcoplasmic reticulum (SR) vesicle Ca2+ uptake and release rates.
Result.
Six weeks exposure of rats to HRHF increased indicators of fatigue, pain behaviors, and [Ca2+]i, the latter implied by around 50–100% increases in pCam, as well as in the Ca2+ handling proteins RyR1 and Casq1 accompanied by an ∼10% increased SR Ca2+ uptake rate in extensor and flexor muscles compared to those of control rats.
This demonstrated a work-related altered myocellular Ca2+ regulation, SR Ca2+ handling, and SR protein expression.
Discussion.
These disturbances may mirror intracellular changes in early stages of human work-related myalgic muscle.
Increased uptake of Ca2+ into the SR may reflect an early adaptation to avoid a sustained detrimental increase in [Ca2+]i similar to the previous findings of deteriorated Ca2+ regulation and impaired function in fatigued human muscle.
American Psychological Association (APA)
Hadrevi, J.& Barbe, Mary F.& Ørtenblad, N.& Frandsen, U.& Boyle, E.& Lazar, S.…[et al.]. 2019. Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125769
Modern Language Association (MLA)
Hadrevi, J.…[et al.]. Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1125769
American Medical Association (AMA)
Hadrevi, J.& Barbe, Mary F.& Ørtenblad, N.& Frandsen, U.& Boyle, E.& Lazar, S.…[et al.]. Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1125769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125769