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Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
Joint Authors
Xu, Xiaofeng
Hu, Haochang
Lin, Ying
Huang, Fangzhong
Ji, Huihui
Li, Yin
Chen, Xiaomin
Lin, Shaoyi
Duan, Shiwei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Coronary heart disease (CHD) is one of the most common causes of death in the world.
Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases.
Short telomeres increase the risk of all-cause death and cardiovascular death.
However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different.
Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls).
We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD.
Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD.
The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study.
American Psychological Association (APA)
Xu, Xiaofeng& Hu, Haochang& Lin, Ying& Huang, Fangzhong& Ji, Huihui& Li, Yin…[et al.]. 2019. Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125774
Modern Language Association (MLA)
Xu, Xiaofeng…[et al.]. Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1125774
American Medical Association (AMA)
Xu, Xiaofeng& Hu, Haochang& Lin, Ying& Huang, Fangzhong& Ji, Huihui& Li, Yin…[et al.]. Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125774