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Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens
Joint Authors
LeMessurier, Kim S.
Palipane, Maneesha
Lin, Yanyan
Samarasinghe, Amali E.
Lew, D. Betty
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Severe asthma with fungal sensitization predominates in the population suffering from allergic asthma, to which there is no cure.
While corticosteroids are the mainstay in current treatment, other means of controlling inflammation may be beneficial.
Herein, we hypothesized that mannan from Saccharomyces cerevisiae would dampen the characteristics of fungal allergic asthma by altering the pulmonary immune responses.
Using wild-type and transgenic mice expressing the human mannose receptor on smooth muscle cells, we explored the outcome of mannan administration during allergen exposure on the pathogenesis of fungal asthma through measurement of cardinal features of disease such as inflammation, goblet cell number, and airway hyperresponsiveness.
Mannan treatment did not alter most hallmarks of allergic airways disease in wild-type mice.
Transgenic mice treated with mannan during allergen exposure had an equivalent response to non-mannan-treated allergic mice except for a prominent granulocytic influx into airways and cytokine availability.
Our studies suggest no role for mannan as an inflammatory regulator during fungal allergy.
American Psychological Association (APA)
Lew, D. Betty& LeMessurier, Kim S.& Palipane, Maneesha& Lin, Yanyan& Samarasinghe, Amali E.. 2018. Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125779
Modern Language Association (MLA)
Lew, D. Betty…[et al.]. Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125779
American Medical Association (AMA)
Lew, D. Betty& LeMessurier, Kim S.& Palipane, Maneesha& Lin, Yanyan& Samarasinghe, Amali E.. Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125779