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The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
Joint Authors
Yao, Kang
Liu, Shaojuan
He, Liuqin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans.
Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes.
As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation.
Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells.
In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans.
American Psychological Association (APA)
Liu, Shaojuan& He, Liuqin& Yao, Kang. 2018. The Antioxidative Function of Alpha-Ketoglutarate and Its Applications. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125784
Modern Language Association (MLA)
Liu, Shaojuan…[et al.]. The Antioxidative Function of Alpha-Ketoglutarate and Its Applications. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125784
American Medical Association (AMA)
Liu, Shaojuan& He, Liuqin& Yao, Kang. The Antioxidative Function of Alpha-Ketoglutarate and Its Applications. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125784