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Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality
Joint Authors
Spencer, Charles
Ramos Muniz, Mireya G.
Palfreeman, Matthew
Setzu, Nicole
Sanchez, Michelle A.
Saenz Portillo, Pamela
Garza, Kristine M.
Gosselink, Kristin L.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Infection with Francisella tularensis, the causative agent of the human disease tularemia, results in the overproduction of inflammatory cytokines, termed the cytokine storm.
Excess metabolic byproducts of obesity accumulate in obese individuals and activate the same inflammatory signaling pathways as F.
tularensis infection.
In addition, elevated levels of leptin in obese individuals also increase inflammation.
Since leptin is produced by adipocytes, we hypothesized that increased fat of obese females may make them more susceptible to F.
tularensis infection compared with lean individuals.
Lean and obese female mice were infected with F.
tularensis and the immunopathology and susceptibility monitored.
Plasma and tissue cytokines were analyzed by multiplex ELISA and real-time RT-PCR, respectively.
Obese mice were more sensitive to infection, developing a more intense cytokine storm, which was associated with increased death of obese mice compared with lean mice.
This enhanced inflammatory response correlated with in vitro bacteria-infected macrophage cultures where addition of leptin led to increased production of inflammatory cytokines.
We conclude that increased basal leptin expression in obese individuals causes a persistent low-level inflammatory response making them more susceptible to F.
tularensis infection and heightening the generation of the immunopathological cytokine storm.
American Psychological Association (APA)
Ramos Muniz, Mireya G.& Palfreeman, Matthew& Setzu, Nicole& Sanchez, Michelle A.& Saenz Portillo, Pamela& Garza, Kristine M.…[et al.]. 2018. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125793
Modern Language Association (MLA)
Ramos Muniz, Mireya G.…[et al.]. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125793
American Medical Association (AMA)
Ramos Muniz, Mireya G.& Palfreeman, Matthew& Setzu, Nicole& Sanchez, Michelle A.& Saenz Portillo, Pamela& Garza, Kristine M.…[et al.]. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125793