Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis
Joint Authors
Fan, Guohua
Ya, Yang
Ni, Xiaoqiong
Hou, Jinpeng
Yu, Rui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To assess the application value of perfusion-weighted imaging (PWI) in early diagnosis, quantitation, and hepatic fibrosis staging by analyzing the related parameters in hepatic fibrosis.
Methods.
A total of 60 rats were randomly divided into the hepatic fibrosis and control groups, and carbon tetrachloride (CCL4) was used to establish the liver fibrosis model.
All rats underwent PWI examination, and the trend of the time-signal intensity curve (TIC, automatically generated by the software) was observed.
Also, the perfusion parameters, maximum signal reduction ratio (SRRmax), time to peak (TTP), and mean transit time (MTT), were analyzed and compared with pathological staging.
Results.
The TIC curve was characterized by slow wash-in and wash-out with a low and wide peak.
The PWI perfusion parameters were statistically significant in specific groups (P<0.05): SRRmax values (control group and F3, F4), TTP, and MTT values (control group and F2–F4, F1 and F3, F1 and F4, and F2 and F4 in addition to TTP values for F1 and F2).
Pearson’s correlation analysis showed a negative correlation of SRRmax with hepatic fibrosis stage (r = −0.439, P<0.05), while TTP and MTT values were positively correlated with hepatic fibrosis stage (TTP, r = 0.798; MTT, r = 0.647; all P<0.001).
Conclusions.
PWI perfusion parameters reflect the degree of hepatic fibrosis, especially TTP and MTT, and PWI is recommended for the early diagnosis of liver fibrosis for timely intervention and treatment of the disease and delaying its progression.
American Psychological Association (APA)
Fan, Guohua& Ya, Yang& Ni, Xiaoqiong& Hou, Jinpeng& Yu, Rui. 2019. Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125817
Modern Language Association (MLA)
Fan, Guohua…[et al.]. Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125817
American Medical Association (AMA)
Fan, Guohua& Ya, Yang& Ni, Xiaoqiong& Hou, Jinpeng& Yu, Rui. Application Value of Magnetic Resonance Perfusion Imaging in the Early Diagnosis of Rat Hepatic Fibrosis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125817