Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population
Joint Authors
Li, Juyi
Cai, Yi
Wang, Zhongjing
Deng, Aiping
Yang, Guoliang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to investigate whether osteopontin (OPN) variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population.
Polymorphisms at the 9175th position in exon 7 of OPN and rs17524488 were genotyped using direct sequencing in 186 unrelated AS patients and 188 ethnically matched healthy controls.
Serum concentration of OPN was measured by enzyme-linked immunosorbent assay (ELISA) in all participants.
AS patients displayed significantly higher OPN serum levels than the controls (P<001).
A heterozygous, novel 9175 T>A in exon 7 of the OPN gene was found in this study.
In healthy controls, subjects carrying the rs17524488 G/G genotype of the OPN display significantly higher OPN serum levels than the GG/GG genotype (P<0.05).
Plasma OPN level is implicated as an early diagnostic marker of AS.
The novel 9175th- (exon 7) position polymorphism of OPN and rs17524488 were related to susceptibility to AS in a Chinese population, the rs17524488 G/G genotype may be involved in the pathogenesis of AS, and the precise molecular mechanism underlying the influence of OPN polymorphisms on the development of AS remains to be determined in the further prospective studies.
American Psychological Association (APA)
Li, Juyi& Cai, Yi& Wang, Zhongjing& Deng, Aiping& Yang, Guoliang. 2018. Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125823
Modern Language Association (MLA)
Li, Juyi…[et al.]. Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125823
American Medical Association (AMA)
Li, Juyi& Cai, Yi& Wang, Zhongjing& Deng, Aiping& Yang, Guoliang. Polymorphisms in the Osteopontin Are Associated with Susceptibility to Ankylosing Spondylitis in a Han Chinese Population. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125823