![](/images/graphics-bg.png)
A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer
Joint Authors
Leung, Gilberto K. K.
Kiang, Karrie Mei Yee
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on different chromosomes.
Adducin is primarily responsible for the assembly of spectrin-actin network that provides physical support to the plasma membrane and mediates signal transduction in various cellular physiological processes upon regulation by protein kinase C-dependent and calcium/calmodulin-dependent pathways.
Abnormal phosphorylation, genetic variations, and alternative splicing of adducin may contribute to alterations in cellular functions involved in pathogenic processes.
These alterations are associated with a wide range of diseases including cancer.
This paper begins with a discussion on how adducin partakes in the structural formation of membrane skeleton, its regulation, and related functional characteristics, followed by a review on the pathogenesis of hypertension, biliary atresia, and cancer with respect to increased disease susceptibility mediated by adducin polymorphism and/or dysregulation.
Given the functional diversity of adducin in different cellular compartments, we aim to provide a knowledge base whereby its pathophysiological roles can be better understood.
More importantly, we aim to provide novel insights that may be of significance in turning the adducin model to clinical application.
American Psychological Association (APA)
Kiang, Karrie Mei Yee& Leung, Gilberto K. K.. 2018. A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125829
Modern Language Association (MLA)
Kiang, Karrie Mei Yee& Leung, Gilberto K. K.. A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1125829
American Medical Association (AMA)
Kiang, Karrie Mei Yee& Leung, Gilberto K. K.. A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125829