Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery
Joint Authors
Skrzep-Poloczek, Bronisława
Stygar, Dominika
Pigłowski, Wojciech
Chełmecka, Elżbieta
Sawczyn, Tomasz
Garłowski, Wojciech
Jochem, Jerzy
Karcz, Konrad Wojciech
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats.
Methods.
A high-fat diet (HF) was given to 28 rats and 28 more were fed with a control diet (CD) for 2 months.
After that, half of each group underwent either DJOS or SHAM surgery.
For the next 2 months, half of the animals in each operation group were kept on the same diet as before and half of them had the diet changed.
After 16 weeks of the experiment RBP4, fetuin-A, and FGF21 plasma levels as well as liver Rbp4, Ahsg, and Fgf21 gene expressions were measured.
Results.
DJOS had a reductive impact on plasma levels of RBP4, fetuin-A, and FGF21 and Rbp4, Ahsg, and Fgf21 relative gene expression in the liver when compared to SHAM.
The HF/HF group expressed significantly higher RBP4 and fetuin-A plasma levels in comparison to the control.
The HF diet used before and/or after surgery led to upregulation of Rbp4, Ahsg, and Fgf21 relative gene expression.
The lowest levels of analyzed parameters were observed in the CD/CD group.
Conclusions.
The efficiency of DJOS surgery, measured by hepatokines’ plasma levels and their gene expressions in the liver, depends on the type of diet applied before and after surgery.
Manipulation of dietary patterns can lead to marked improvements in metabolic profile after DJOS surgery.
American Psychological Association (APA)
Stygar, Dominika& Pigłowski, Wojciech& Chełmecka, Elżbieta& Skrzep-Poloczek, Bronisława& Sawczyn, Tomasz& Garłowski, Wojciech…[et al.]. 2018. Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125832
Modern Language Association (MLA)
Stygar, Dominika…[et al.]. Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1125832
American Medical Association (AMA)
Stygar, Dominika& Pigłowski, Wojciech& Chełmecka, Elżbieta& Skrzep-Poloczek, Bronisława& Sawczyn, Tomasz& Garłowski, Wojciech…[et al.]. Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1125832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125832