Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo

Joint Authors

Hu, Yuanliang
Du, Hongxu
Zhang, Shuaibing
He, Miao
Ming, Ke
Wang, Jinli
Yuan, Wenjuan
Qiao, Mingyu
Wu, Yi
Liu, Jiaguo
Wang, Deyun

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-04-04

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Rabbit hemorrhagic disease (RHD) is an acute, high fatal contagious disease induced by rabbit hemorrhagic disease virus (RHDV) with acute severe hepatic injury and causes huge economic loss worldwide.

In order to develop an effective and reliable drug to treat this disease in clinic, a prescription formulated with baicalin, linarin, icariin, and notoginsenoside R1 (BLIN) according to the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine was applied to investigate its curative effects against RHD in vivo.

The preliminary study results showed that BLIN prescription exerted good curative effect on RHD therapy.

To further validate the curative effect and to investigate the possible related curative mechanisms of this drug, the survival rates, the plasma biochemical indexes of hepatic function, the plasma evaluation indexes of oxidative injury, and the RHDV gene expression levels were detected and then the correlation among these indexes was also analyzed.

These results showed that BLIN prescription could significantly increase the survival rate, reduce the hepatic injury severity, alleviate the oxidative injury, and decrease the RHDV gene expression level in rabbits infected with RHDV.

All these results indicate that BLIN prescription possesses outstanding curative effect against RHD, and the curative mechanism may be related to its antioxidant and anti-RHDV activities.

Therefore, this prescription can be expected to be exploited into a new candidate for RHD therapy in clinic.

American Psychological Association (APA)

Du, Hongxu& Zhang, Shuaibing& He, Miao& Ming, Ke& Wang, Jinli& Yuan, Wenjuan…[et al.]. 2019. Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125894

Modern Language Association (MLA)

Du, Hongxu…[et al.]. Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125894

American Medical Association (AMA)

Du, Hongxu& Zhang, Shuaibing& He, Miao& Ming, Ke& Wang, Jinli& Yuan, Wenjuan…[et al.]. Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125894

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1125894