Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice
Joint Authors
Wang, Qi
Zhang, Shi-Jie
Wang, Xin-Chen
Xu, Yu-Min
Li, Hong-Ying
Wu, Chun-Ying
Xu, Ting-Ting
Luo, Na-Chuan
Quan, Shi-Jian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cognitive dysfunction is characterized as the gradual loss of learning ability and cognitive function, as well as memory impairment.
Jiao-tai-wan (JTW), a Chinese medicine prescription including Coptis chinensis and cinnamon, is mainly used for the treatment of insomnia, while the effect of JTW in improving cognitive function has not been reported.
In this study, we employed a scopolamine- (SCOP-) treated learning and memory deficit model to explore whether JTW could alleviate cognitive dysfunction.
In behavioral experiments, Morris water maze, Y-maze, fearing condition test, and novel object discrimination test were conducted.
Results showed that oral administration of JTW (2.1 g/kg, 4.2 g/kg, and 8.4 g/kg) can effectively promote the ability of spatial recognition, learning and memory, and the memory ability of fresh things of SCOP-treated mice.
In addition, the activity of acetylcholinesterase (AChE) was effectively decreased; the activity of choline acetyltransferase (ChAT) and concentration of acetylcholine (Ach) were improved after JTW treatment in both hippocampus and cortex of SCOP-treated mice.
JTW effectively ameliorated oxidative stress because of decreased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) and increased the activities of superoxide dismutase (SOD) and catalase (CAT) in hippocampus and cortex.
Furthermore, JTW promotes the expressions of neurotrophic factors including postsynaptic density protein 95 (PSD95) and synaptophysin (SYN) and brain-derived neurotrophic factor (BDNF) in both hippocampus and cortex.
Nissl’s staining shows that the neuroprotective effect of JTW was very effective.
To sum up, JTW might be a promising candidate for the treatment of cognitive dysfunction.
American Psychological Association (APA)
Wang, Xin-Chen& Xu, Yu-Min& Li, Hong-Ying& Wu, Chun-Ying& Xu, Ting-Ting& Luo, Na-Chuan…[et al.]. 2018. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125901
Modern Language Association (MLA)
Wang, Xin-Chen…[et al.]. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1125901
American Medical Association (AMA)
Wang, Xin-Chen& Xu, Yu-Min& Li, Hong-Ying& Wu, Chun-Ying& Xu, Ting-Ting& Luo, Na-Chuan…[et al.]. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1125901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125901