Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease
Joint Authors
Pham, Hanh M.
Xu, Anna
Schriner, Samuel E.
Sevrioukov, Evgueni A.
Jafari, Mahtab
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cinnamon extract has been reported to have positive effects in fruit fly and mouse models for Alzheimer’s disease (AD).
However, cinnamon contains numerous potential active compounds that have not been individually evaluated.
The main objective of this study was to evaluate the impact of cinnamaldehyde, a known putative active compound in cinnamon, on the lifespan and healthspan of Drosophila melanogaster models for Alzheimer’s disease, which overexpress Aβ42 and MAPT (Tau).
We found that cinnamaldehyde significantly improved the lifespan of both AD and non-AD flies.
Cinnamaldehyde also improved the healthspan of AD flies overexpressing the Tau protein by improving climbing ability, evaluated by rapid iterative negative geotaxis (RING), and improving short-term memory, evaluated by a courtship conditioning assay.
Cinnamaldehyde had no positive impact on the healthspan of AD flies overexpressing the Aβ42 protein.
American Psychological Association (APA)
Pham, Hanh M.& Xu, Anna& Schriner, Samuel E.& Sevrioukov, Evgueni A.& Jafari, Mahtab. 2018. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125919
Modern Language Association (MLA)
Pham, Hanh M.…[et al.]. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1125919
American Medical Association (AMA)
Pham, Hanh M.& Xu, Anna& Schriner, Samuel E.& Sevrioukov, Evgueni A.& Jafari, Mahtab. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1125919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125919