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Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors
Joint Authors
Maldonado-Bernal, Carmen
Abarca-Merlin, D. M.
Alvarez-Arellano, L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In recent years, progress has been made in understanding the pathological, genetic, and molecular heterogeneity of central nervous system (CNS) tumors.
However, improvements in risk classification, prognosis, and treatment have not been sufficient.
Currently, great importance has been placed to the tumor microenvironment and the immune system, which are very important components that influence the establishment and development of tumors.
Toll-like receptors (TLRs) are innate immunite system sensors of a wide variety of molecules, such as those associated with microorganisms and danger signals.
TLRs are expressed on many cells, including immune cells and nonimmune cells such as neurons and cancer cells.
In the tumor microenvironment, activation of TLRs plays dual antitumoral (dendritic cells, cytotoxic T cells, and natural killer cells activation) and protumoral effects (tumor cell proliferation, survival, and resistance to chemotherapy) and constitutes an area of opportunities and challenges in the development of new therapeutic strategies.
Several clinical trials have been carried out, and others are currently in process; however, the results obtained to date have been contradictory and have not led to a definitive position about the use of TLR agonists in adjuvant therapy during the treatment of central nervous system (CNS) tumors.
In this review, we focus on recent advances in TLR agonists as immunotherapies for treatment of CNS tumors.
American Psychological Association (APA)
Abarca-Merlin, D. M.& Maldonado-Bernal, Carmen& Alvarez-Arellano, L.. 2019. Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125943
Modern Language Association (MLA)
Abarca-Merlin, D. M.…[et al.]. Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1125943
American Medical Association (AMA)
Abarca-Merlin, D. M.& Maldonado-Bernal, Carmen& Alvarez-Arellano, L.. Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1125943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125943