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Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome
Joint Authors
Fernandes-Cerqueira, Cátia
Sampaio-Maia, Benedita
Simões-Silva, Liliana
Pestana, Manuel
Janete, Quelhas-Santos
Isabel, Soares-Silva
Roberto, Roncon-Albuquerque
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Puromycin aminonucleoside-induced nephrotic syndrome (PAN-NS) is characterized by cardiac remodeling and increased local inflammatory activity.
Patients with NS and animal models of NS have vitamin D3 deficiency.
The aim of the present study was to evaluate the influence of calcitriol on cardiac remodeling and local inflammatory state in PAN-NS rat model.
Male Sprague-Dawley rats were injected with PAN or vehicle on day 0.
PAN and control rats were divided into two subgroups for the administration of calcitriol (PAN-D and Ct-D groups) or the vehicle (PAN-V and Ct-V groups) during 21 days.
On day 21, the renal function, metabolic balance, calcitriol and FGF-23 plasma levels, prohypertrophy and proinflammatory markers (ET-1, TGF-β1, TNF-α, and IL-1β), and calcium signaling molecules (PLB and SERCA-2a) were evaluated.
Twenty-one days after injection, PAN-V group presented cardiac hypertrophy and a modulation of proinflammatory markers local expression.
Calcitriol treatment of PAN rats prevented cardiac hypertrophy and was associated with marked reduction in the cardiac expression levels of proinflammatory markers.
Our results suggest that vitamin D3 deficiency in PAN-NS may contribute to cardiac remodeling and to the increase in local inflammatory activity.
Calcitriol treatment prevents both cardiac repercussions and local inflammatory processes in PAN-NS.
American Psychological Association (APA)
Fernandes-Cerqueira, Cátia& Janete, Quelhas-Santos& Sampaio-Maia, Benedita& Simões-Silva, Liliana& Isabel, Soares-Silva& Roberto, Roncon-Albuquerque…[et al.]. 2018. Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125951
Modern Language Association (MLA)
Fernandes-Cerqueira, Cátia…[et al.]. Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125951
American Medical Association (AMA)
Fernandes-Cerqueira, Cátia& Janete, Quelhas-Santos& Sampaio-Maia, Benedita& Simões-Silva, Liliana& Isabel, Soares-Silva& Roberto, Roncon-Albuquerque…[et al.]. Calcitriol Prevents Cardiovascular Repercussions in Puromycin Aminonucleoside-Induced Nephrotic Syndrome. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125951