Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide
Joint Authors
Hu, Qingqiao
Chen, Xiangxun
Liu, Juan
Di, Wenjuan
Lv, Shan
Tang, Lijun
Ding, Guoxian
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The peptide (CKGGRAKDC-NH2) specifically targets the brown adipose tissue (BAT).
Here we applied this peptide coupled with polyethylene glycol (PEG)-coated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to detect BAT in vivo by magnetic resonance imaging (MRI).
The peptide was conjugated with PEG-coated USPIO nanoparticles to obtain targeted USPIO nanoprobes.
Then the nanoprobes for BAT were evaluated in mice.
T2⁎-weighted images were performed, precontrast and postcontrast USPIO nanoparticles.
Finally, histological analyses proved the specific targeting.
The specificity of targeted USPIO nanoprobes was observed in mice.
The T2⁎ relaxation time of BAT in the targeted group decreased obviously compared to the controls (P<0.001).
Prussian blue staining and transmission electron microscope confirmed the specific presence of iron oxide.
This study demonstrated that peptide (CKGGRAKDC-NH2) coupled with PEG-coated USPIO nanoparticles could identify BAT noninvasively in vivo with MRI.
American Psychological Association (APA)
Hu, Qingqiao& Chen, Xiangxun& Liu, Juan& Di, Wenjuan& Lv, Shan& Tang, Lijun…[et al.]. 2018. Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125958
Modern Language Association (MLA)
Hu, Qingqiao…[et al.]. Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125958
American Medical Association (AMA)
Hu, Qingqiao& Chen, Xiangxun& Liu, Juan& Di, Wenjuan& Lv, Shan& Tang, Lijun…[et al.]. Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125958