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Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALBc Mice
Joint Authors
Olivier, Martin
Barrios-Correa, Alberto A.
Estrada, José A.
Martel, Caroline
López-Santiago, Rubén
Contreras, Irazú
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Nonnutritive sweetener use is a common practice worldwide.
Although considered safe for human consumption, accumulating evidence suggests these compounds may affect metabolic homeostasis; however, there is no consensus on the role of frequent sweetener intake in appetite and weight loss.
We sought to determine whether frequent intake of commercial sweeteners induces changes in the JAK2/STAT3 signaling pathway in the brain of mice, as it is involved in the regulation of appetite and body composition.
We supplemented adult BALB/c mice with sucrose, steviol glycosides (SG), or sucralose, daily, for 6 weeks.
After supplementation, we evaluated body composition and expression of total and phosphorylated JAK2, STAT3, and Akt, as well as SOCS3 and ObRb, in brain tissue.
Our results show that frequent intake of commercial SG decreases energy intake, adiposity, and weight gain in male animals, while increasing the expression of pJAK2 and pSTAT3 in the brain, whereas sucralose increases weight gain and pJAK2 expression in females.
Our results suggest that chronic intake of commercial sweeteners elicits changes in signaling pathways that have been related to the control of appetite and energy balance in vivo, which may have relevant consequences for the nutritional state and long term health of the organism.
American Psychological Association (APA)
Barrios-Correa, Alberto A.& Estrada, José A.& Martel, Caroline& Olivier, Martin& López-Santiago, Rubén& Contreras, Irazú. 2018. Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALBc Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1125970
Modern Language Association (MLA)
Barrios-Correa, Alberto A.…[et al.]. Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALBc Mice. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1125970
American Medical Association (AMA)
Barrios-Correa, Alberto A.& Estrada, José A.& Martel, Caroline& Olivier, Martin& López-Santiago, Rubén& Contreras, Irazú. Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALBc Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1125970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125970