p38TFHIF-α Signaling Pathway Participates in the Progression of CIPN in Mice
Joint Authors
Yang, Yang
Hu, Liang
Wang, Chaoyu
Yang, Xing
Song, Ling
Jiang, Chunyi
Li, Yan
Li, Tianxi
Liu, Wen-Tao
Feng, Jifeng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chemotherapy induced peripheral neuropathy (CIPN) is a serious adverse effect of chemotherapeutics with limited pathogenetic mechanism been known.
Whether microcirculatory disturbance is involved in CIPN has not been reported.
Considering that tissue factor (TF) is an endogenous coagulation factor, we hypothesize CIPN may be induced by the high expression of TF in macrophages and sciatic nerve, which induces the molecular signal related to ischemia and hypoxia.
Oxaliplatin (L-OHP) was used to establish CIPN model.
Von Frey Hairs was used to measure nociception.
The murine macrophage cell line Raw 264.7 was used for cell experiments.
Gelatin zymography and western blotting were used to measure the activity or expression of protein.
TF expression and MMP-9/2 activity in sciatic nerve and blood are significantly increased by L-OHP.
L-OHP increased the release of HSP70 from macrophage and enhanced the expression of p-p38 and HIF-1α in vivo and in vitro.
Hirudin significantly suppressed the overexpression of p38, HIF-1α and activation of MMP-9/2 induced by L-OHP and attenuated CIPN in mice.
This study suggests that a novel HSP70-TLR-4-p38-TF-HIF-1a axis may play a pivotal role in the pathological process of CIPN.
It is also shown that the use of anticoagulant Hirudin can inhibit the above mechanisms and improve CIPN.
American Psychological Association (APA)
Yang, Yang& Hu, Liang& Wang, Chaoyu& Yang, Xing& Song, Ling& Jiang, Chunyi…[et al.]. 2019. p38TFHIF-α Signaling Pathway Participates in the Progression of CIPN in Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125976
Modern Language Association (MLA)
Yang, Yang…[et al.]. p38TFHIF-α Signaling Pathway Participates in the Progression of CIPN in Mice. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1125976
American Medical Association (AMA)
Yang, Yang& Hu, Liang& Wang, Chaoyu& Yang, Xing& Song, Ling& Jiang, Chunyi…[et al.]. p38TFHIF-α Signaling Pathway Participates in the Progression of CIPN in Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1125976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125976