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Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer
Joint Authors
Feng, Jianguo
Dong, Yao
Huaying, Sheng
Danying, Wan
Chihong, Zhu
Ruibin, Jiang
Xiaojiang, Sun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Because NSCLC has poor overall prognosis and is frequently diagnosed at later stage, we aimed to seek novel diagnosis biomarkers or therapy target of the disease in this study.
Fructose-1,6-bisphosphatase 1 (FBP1) is a rate-limiting enzyme in gluconeogenesis, which was usually lost in NSCLC due to abnormal methylation in promoter DNA sequence.
The clinical data indicated that the methylation rate in FBP1 gene promoter was negatively related to the overall survival of the NSCLC patients.
DNA methylation transferase inhibitor 5-aza treatment could significantly increase both expression levels of mRNA and protein in A549 cell line.
On the other hand, silence of FBP1 in H460 cell line by using specific siRNA against FBP1 dramatically improved the cell proliferation and cell migration according to the date of FACS and transwell assays.
All these findings implied the important roles of FBP1 expression in lung cancer development and progression and the potential use of the methylation status detected in FBP1 promoter region as a novel predictor for prognosis and therapeutic target for NSCLC patients.
American Psychological Association (APA)
Dong, Yao& Huaying, Sheng& Danying, Wan& Chihong, Zhu& Ruibin, Jiang& Xiaojiang, Sun…[et al.]. 2018. Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126056
Modern Language Association (MLA)
Dong, Yao…[et al.]. Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126056
American Medical Association (AMA)
Dong, Yao& Huaying, Sheng& Danying, Wan& Chihong, Zhu& Ruibin, Jiang& Xiaojiang, Sun…[et al.]. Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126056