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Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease
Joint Authors
Radhakrishnan, Ammu
Magalingam, Kasthuri Bai
Ping, Ng Shee
Haleagrahara, Nagaraja
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neurodegenerative diseases are hereditary or sporadic conditions that result in the progressive loss of the structure and function of neurons as well as neuronal death.
Although a range of diseases lie under this umbrella term, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases that affect a large population around the globe.
Alzheimer’s disease is characterized by the abnormal accumulation of extracellular amyloid-β plaques and intraneuronal neurofibrillary tangles in brain regions and manifests as a type of dementia in aged individuals that results in memory loss, multiple cognitive abnormalities, and intellectual disabilities that interfere with quality of life.
Since the discovery of AD, a wealth of new information has emerged that delineates the causes, mechanisms of disease, and potential therapeutic agents, but an effective remedy to cure the diseases has not been identified yet.
This could be because of the complexity of the disease process, as it involves various contributing factors that include environmental factors and genetic predispositions.
This review summarizes the current understanding on neurodegenerative mechanisms that lead to the emergence of the pathology of AD.
American Psychological Association (APA)
Magalingam, Kasthuri Bai& Radhakrishnan, Ammu& Ping, Ng Shee& Haleagrahara, Nagaraja. 2018. Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126065
Modern Language Association (MLA)
Magalingam, Kasthuri Bai…[et al.]. Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1126065
American Medical Association (AMA)
Magalingam, Kasthuri Bai& Radhakrishnan, Ammu& Ping, Ng Shee& Haleagrahara, Nagaraja. Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1126065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126065