Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis
Joint Authors
Xu, Enjie
Jiang, Heng
Lin, Tao
Zhou, Xuhui
Ji, Zhe
Ma, Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteosarcoma is one of the most common malignant tumors in children and adolescents and is characterized by early metastasis.
High-mobility group N (HMGN) domains are involved in the development of several tumors.
Our previous study found that HMGN5 is highly expressed in osteosarcoma tissues and knockdown of HMGN5 inhibits migration and invasion of U-2 OS and Saos-2 cells.
A hypoxic environment is commonly found in solid tumors such as osteosarcoma and is likely to be associated with tumor metastasis, so we further explored the relationship between HMGN5 and the hypoxic environment.
Hypoxia-inducible factor 1A (HIF1A) is an adaptive factor in the hypoxic environment.
We found that HIF1A and HMGN5 were upregulated in osteosarcoma (OS) cells cultured in the hypoxic environment, and the results of overexpression and knockdown experiments showed that HIF1A upregulated the transcription factor GATA1 and further promoted the expression of HMGN5.
In addition, MMP2 and MMP9 were subsequently upregulated through the c-jun pathway, and finally, this promoted the migration and invasion of OS cells.
It is suggested that HMGN5 may be an important downstream factor for HIF1A to promote osteosarcoma metastasis.
It has an important clinical significance for the selection of therapeutic targets for osteosarcoma.
American Psychological Association (APA)
Xu, Enjie& Ji, Zhe& Jiang, Heng& Lin, Tao& Ma, Jun& Zhou, Xuhui. 2019. Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126119
Modern Language Association (MLA)
Xu, Enjie…[et al.]. Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1126119
American Medical Association (AMA)
Xu, Enjie& Ji, Zhe& Jiang, Heng& Lin, Tao& Ma, Jun& Zhou, Xuhui. Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1126119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126119