The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors
Joint Authors
Qneibi, Mohammad
Jaradat, Nidal
Hawash, Mohammed
Natsheh, Abdel-Razzak
Yousef, Remah
AbuHasan, Qais
Zaid, A. N.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lavandula dentata L.
and Origanum syriacum L.
essential oils have numerous health benefits and properties, such as possessing common components with a variant degree of depressive actions in the central nervous system.
We investigated the depressive property of these oils on AMPA receptors, which are responsible for most of the fast-excitatory neurotransmission in the CNS and play a critical role in synaptic plasticity.
Since excessive activation of AMPARs has been linked to neurotoxicity leading to various pathologies, we hypothesize that these oils have a neuroprotective role by acting directly on the kinetics of AMPARs.
Using Gas Chromatography-Mass Spectrometry (GC/MS) and patch-clamp electrophysiology, the essential oils of L.
dentata flowers and O.
syriacum leaves were characterized and the whole cell currents were measured with and without the administration of the oils onto HEK293 cells.
The current study results showed that the biophysical properties of AMPA receptor subunits showed a decrease in desensitization rate of GluA1 and GluA2 homomers, using O.
syriacum, while administering L.
dentata oil decreased the desensitization rate of GluA1 and GluA2 homomers, as well as GluA1/2 heteromers.
As for the deactivation rate, both oils slowed the deactivation kinetics of all AMPA receptor subunits.
Intriguingly, between the two oils, the effect of desensitization and deactivation was of a greater significance for L.
dentata oil than O.
syriacum.
Our data suggest that the two oils contain components that are essential to identify, as those active components underlie the oils’ neuronal depressive properties reported, and to extract them to synthesize a potent neuroprotective drug to treat neurological diseases potentially.
American Psychological Association (APA)
Qneibi, Mohammad& Jaradat, Nidal& Hawash, Mohammed& Zaid, A. N.& Natsheh, Abdel-Razzak& Yousef, Remah…[et al.]. 2019. The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126126
Modern Language Association (MLA)
Qneibi, Mohammad…[et al.]. The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1126126
American Medical Association (AMA)
Qneibi, Mohammad& Jaradat, Nidal& Hawash, Mohammed& Zaid, A. N.& Natsheh, Abdel-Razzak& Yousef, Remah…[et al.]. The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126126