Dempster-Shafer Theory for the Prediction of Auxin-Response Elements (AuxREs) in Plant Genomes
Joint Authors
Rebaï, Ahmed
Ben Ayed, Rayda
Sghaier, Nesrine
Ben Marzoug, Riadh
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Auxin is a major regulator of plant growth and development; its action involves transcriptional activation.
The identification of Auxin-response element (AuxRE) is one of the most important issues to understand the Auxin regulation of gene expression.
Over the past few years, a large number of motif identification tools have been developed.
Despite these considerable efforts provided by computational biologists, building reliable models to predict regulatory elements has still been a difficult challenge.
In this context, we propose in this work a data fusion approach for the prediction of AuxRE.
Our method is based on the combined use of Dempster-Shafer evidence theory and fuzzy theory.
To evaluate our model, we have scanning the DORNRÖSCHEN promoter by our model.
All proven AuxRE present in the promoter has been detected.
At the 0.9 threshold we have no false positive.
The comparison of the results of our model and some previous motifs finding tools shows that our model can predict AuxRE more successfully than the other tools and produce less false positive.
The comparison of the results before and after combination shows the importance of Dempster-Shafer combination in the decrease of false positive and to improve the reliability of prediction.
For an overall evaluation we have chosen to present the performance of our approach in comparison with other methods.
In fact, the results indicated that the data fusion method has the highest degree of sensitivity (Sn) and Positive Predictive Value (PPV).
American Psychological Association (APA)
Sghaier, Nesrine& Ben Ayed, Rayda& Ben Marzoug, Riadh& Rebaï, Ahmed. 2018. Dempster-Shafer Theory for the Prediction of Auxin-Response Elements (AuxREs) in Plant Genomes. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126142
Modern Language Association (MLA)
Sghaier, Nesrine…[et al.]. Dempster-Shafer Theory for the Prediction of Auxin-Response Elements (AuxREs) in Plant Genomes. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126142
American Medical Association (AMA)
Sghaier, Nesrine& Ben Ayed, Rayda& Ben Marzoug, Riadh& Rebaï, Ahmed. Dempster-Shafer Theory for the Prediction of Auxin-Response Elements (AuxREs) in Plant Genomes. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126142