Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress Syndrome
Joint Authors
Harrell, Carl Randall
Jovicic, Biljana Popovska
Djonov, Valentin
Volarevic, Vladislav
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the development of a new coronavirus disease (COVID-19), is a highly transmittable virus which, in just ten months, infected more than 40 million people in 214 countries worldwide.
After inhalation, aerosols containing SARS-CoV-2 penetrate to the depths of the lungs and cause severe pneumonia, alveolar injury, and life-threatening acute respiratory distress syndrome (ARDS).
Since there are no specific drugs or vaccines available to cure or prevent COVID-19 infection and COVID-19-related ARDS, a new therapeutic agent which will support oxygen supply and, at the same time, efficiently alleviate SARS-CoV-2-induced lung inflammation is urgently needed.
Due to their potent immuno- and angiomodulatory characteristics, mesenchymal stem cells (MSCs) may increase oxygen supply in the lungs and may efficiently alleviate ongoing lung inflammation, including SARS-CoV-2-induced ARDS.
In this review article, we described molecular mechanisms that are responsible for MSC-based modulation of immune cells which play a pathogenic role in the development of SARS-CoV-2-induced ARDS and we provided a brief outline of already conducted and ongoing clinical studies that increase our understanding about the therapeutic potential of MSCs and their secretome in the therapy of COVID-19-related ARDS.
American Psychological Association (APA)
Harrell, Carl Randall& Jovicic, Biljana Popovska& Djonov, Valentin& Volarevic, Vladislav. 2020. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress Syndrome. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126143
Modern Language Association (MLA)
Harrell, Carl Randall…[et al.]. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress Syndrome. Analytical Cellular Pathology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1126143
American Medical Association (AMA)
Harrell, Carl Randall& Jovicic, Biljana Popovska& Djonov, Valentin& Volarevic, Vladislav. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of SARS-CoV-2-Induced Acute Respiratory Distress Syndrome. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126143