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MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI
Joint Authors
Hu, Bangchuan
Hong, Jun
Xu, Liang
Zheng, Yang
Shao, Zi-Qiang
Zhang, Run
Yang, Xiang-Hong
Sun, Ren-Hua
Mo, Shi-Jing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fibroblast growth factor-inducible molecule 14 (Fn14) plays a principal role in triggering tubular damage during septic acute kidney injury (AKI).
Here, we explore the mechanism underlying Fn14 deregulation in septic AKI.
We identify Fn14 as a bona fide target of miR-19a, which directly binds to 3′ UTR of Fn14 for repression independent of cylindromatosis (CYLD), the deubiquitinase (DUB) downstream of miR-19a, and thereby antagonizes the LPS-induced tubular cell apoptosis.
Genetic ablation of Fn14, but not of CYLD, abolishes the ability of miR-19a to antagonize the tubular apoptosis by lipopolysaccharide (LPS).
In mice, systemic delivery of miR-19a confers protection against septic AKI.
Our findings implicate that miR-19a may serve as a promising therapeutic candidate in the prevention of septic AKI.
American Psychological Association (APA)
Hong, Jun& Hu, Bangchuan& Xu, Liang& Zheng, Yang& Shao, Zi-Qiang& Zhang, Run…[et al.]. 2020. MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126156
Modern Language Association (MLA)
Hong, Jun…[et al.]. MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI. Analytical Cellular Pathology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1126156
American Medical Association (AMA)
Hong, Jun& Hu, Bangchuan& Xu, Liang& Zheng, Yang& Shao, Zi-Qiang& Zhang, Run…[et al.]. MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126156