MCMs in Cancer: Prognostic Potential and Mechanisms
Joint Authors
Xu, Haifeng
Zheng, Yongchang
Shi, Yue
Yu, Si
Chen, Yang
Wang, Guanqun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells.
Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication initiation and play vital roles in controlling replication times within a cell cycle.
Overexpressed MCMs are detected in various cancerous tissues and cancer cell lines.
Previous studies have proposed MCMs as promising proliferation markers in cancers, while the prognostic values remain controversial and the underlying mechanisms remain unascertained.
This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family.
Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed.
This work also offers insight into the mechanisms of MCMs prompting carcinogenesis and adverse prognosis, providing information for future research.
Finally, MCMs in liver cancer are specifically discussed, and future perspectives are provided.
American Psychological Association (APA)
Yu, Si& Wang, Guanqun& Shi, Yue& Xu, Haifeng& Zheng, Yongchang& Chen, Yang. 2020. MCMs in Cancer: Prognostic Potential and Mechanisms. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126166
Modern Language Association (MLA)
Yu, Si…[et al.]. MCMs in Cancer: Prognostic Potential and Mechanisms. Analytical Cellular Pathology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1126166
American Medical Association (AMA)
Yu, Si& Wang, Guanqun& Shi, Yue& Xu, Haifeng& Zheng, Yongchang& Chen, Yang. MCMs in Cancer: Prognostic Potential and Mechanisms. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126166