Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model

Joint Authors

Hou, Xiaohua
Bai, Tao
Zhang, Lei
Wang, Huan
Qian, Wei
Song, Jun

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-01-30

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Aim.

To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with Bifidobacterium longum.

Methods.

Mice visceral hypersensitivity was induced by Trichinella spiralis.

After 8 weeks, they were divided into three groups (controls, Bifidobacterium longum, and fecal microbiota transplantation) and were daily treated by gavage with 0.2 ml PBS, Bifidobacterium longum HB55020, or fecal microbiota for 7 days.

Visceral hypersensitivity was tested with abdominal withdrawal reflex.

Permeability of colon epithelium was assessed with Ussing chamber.

Results.

After administration of Bifidobacterium longum, compared with mice in postinfectious group, mice had higher pain threshold (p<0.05).

After administration of fecal microbiota, compared with mice in postinfectious group, mice had higher pain threshold (p<0.05).

Fecal microbiota transplantation was as effective as Bifidobacterium in relieving visceral hypersensitivity.

Administration of Bifidobacterium longum or fecal microbiota transplantation improved colon epithelium permeability.

Expression of occluding-1 was increased.

Conclusion.

Manipulation of microbiota is effective in relieving visceral hypersensitivity.

Fecal microbiota transplantation is as effective as Bifidobacterium longum administration.

American Psychological Association (APA)

Bai, Tao& Zhang, Lei& Wang, Huan& Qian, Wei& Song, Jun& Hou, Xiaohua. 2018. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126167

Modern Language Association (MLA)

Bai, Tao…[et al.]. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126167

American Medical Association (AMA)

Bai, Tao& Zhang, Lei& Wang, Huan& Qian, Wei& Song, Jun& Hou, Xiaohua. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126167

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1126167