Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model
Joint Authors
Hou, Xiaohua
Bai, Tao
Zhang, Lei
Wang, Huan
Qian, Wei
Song, Jun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with Bifidobacterium longum.
Methods.
Mice visceral hypersensitivity was induced by Trichinella spiralis.
After 8 weeks, they were divided into three groups (controls, Bifidobacterium longum, and fecal microbiota transplantation) and were daily treated by gavage with 0.2 ml PBS, Bifidobacterium longum HB55020, or fecal microbiota for 7 days.
Visceral hypersensitivity was tested with abdominal withdrawal reflex.
Permeability of colon epithelium was assessed with Ussing chamber.
Results.
After administration of Bifidobacterium longum, compared with mice in postinfectious group, mice had higher pain threshold (p<0.05).
After administration of fecal microbiota, compared with mice in postinfectious group, mice had higher pain threshold (p<0.05).
Fecal microbiota transplantation was as effective as Bifidobacterium in relieving visceral hypersensitivity.
Administration of Bifidobacterium longum or fecal microbiota transplantation improved colon epithelium permeability.
Expression of occluding-1 was increased.
Conclusion.
Manipulation of microbiota is effective in relieving visceral hypersensitivity.
Fecal microbiota transplantation is as effective as Bifidobacterium longum administration.
American Psychological Association (APA)
Bai, Tao& Zhang, Lei& Wang, Huan& Qian, Wei& Song, Jun& Hou, Xiaohua. 2018. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126167
Modern Language Association (MLA)
Bai, Tao…[et al.]. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126167
American Medical Association (AMA)
Bai, Tao& Zhang, Lei& Wang, Huan& Qian, Wei& Song, Jun& Hou, Xiaohua. Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126167