The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes
Joint Authors
Alsarhan, Ali
Amawi, Kawther Faisal
Al-Mazari, Inas Saleh
Hurirah, Hashem Abu
Alkhatib, Ahed J.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Diabetes is increasingly prevalent at global level and associated with various impacts including the male reproductive system.
Aims.
This research is aimed at investigating the influence of diabetes on the localization and expression of HSP90 and iNOS in the testicular tissue of diabetic rats.
Methods.
A diabetic model was developed through a single injection of alloxan monohydrate intraperitoneally (purchased from Sigma-Aldrich) 120 mg/kg body weight following fasting for 12 hrs.
The experiment involved two groups, the control and diabetic groups with 10 albino rats in each group.
Diabetes was considered if glucose concentration was ≥200 mg/dl.
The experiment duration was for one month.
After the experiment had finished, all rats were terminated and prepared for routine histological and immunohistochemical examination.
Results.
The results revealed that diabetes caused morphological changes at histological level in testicular tissue.
Immunohistochemical examination showed that diabetes significantly upregulated the expression of both HSP90 and iNOS in the testicular tissue of diabetic rats as compared with that of the control group (p<0.001).
Conclusion.
Diabetes may induce adverse health effects on the male reproduction through upregulation of HSP90 and iNOS in the testicular tissue of diabetic rats.
American Psychological Association (APA)
Alsarhan, Ali& Amawi, Kawther Faisal& Al-Mazari, Inas Saleh& Hurirah, Hashem Abu& Alkhatib, Ahed J.. 2020. The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126168
Modern Language Association (MLA)
Alsarhan, Ali…[et al.]. The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes. Analytical Cellular Pathology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1126168
American Medical Association (AMA)
Alsarhan, Ali& Amawi, Kawther Faisal& Al-Mazari, Inas Saleh& Hurirah, Hashem Abu& Alkhatib, Ahed J.. The Compound Expression of HSP90 and INOS in the Testis of Diabetic Rats as Cellular and Pathologic Adverse Effects of Diabetes. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126168