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In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species
Joint Authors
Priymenko, Nathalie
Shah, Syed Uzair A.
Rauf, Abdur
Abu-Izneid, Tareq
Abdelhady, Mohamed I. S.
Céline, Domange
Mansour, Nashwa
Patel, Seema
Wadood, Abdul
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Hypochaeris radicata (flatweed) from the family Asteraceae is a medicinal plant found in Europe, Middle East, and India.
In folkloric medication, it is used to heal jaundice, dyspepsia, constipation, rheumatism, and hypoglycemia as well as renal problems.
Leaves and roots of the plant have antioxidant and antibacterial properties.
The plant is a rich source of pharmacologically active phytochemicals; however, it is explored scantily.
The objective of the current study was to identify the chemical composition and investigate the in vivo biological potency of crude extracts of this plant.
Methods.
The crude extract and the fractions were screened for various phytochemical groups of constituents following standard procedures.
The acute toxicity was assayed for safe range of dose determination.
The analgesic potential of the extract and fractions was assessed by acetic acid-induced writhing test.
The muscle-relaxant activity was examined by standard inclined-plane test and traction test.
Sedative potential of extract/fractions was assessed by using standard white wood procedures.
Furthermore, docking analysis of two compounds present in the ethyl acetate fraction of the plant was assessed against 3D cyclooxygenase-1 and -2 (COX-1 and COX-2).
Results.
The extract/fractions of H.
radicata showed significant analgesic effect in in vivo model of peripheral algesia.
The docking analysis of previously isolated molecules from the plant also exhibited promising interaction with COX-1 and COX-2.
Also, the plant has a mild sedative and muscle-relaxant potential.
Thus, our study provided pharmacological rationale for the traditional uses of the plant as analgesic and anti-inflammatory remedy.
Conclusion.
The crude extracts and fractions exhibited excellent activity due to active phytochemicals.
These active phytochemicals also exhibited promising interaction with COX-1 and COX-2.
These findings directed researcher to isolate active compounds from H.
radicata which may be used as a potential source of active secondary metabolites.
American Psychological Association (APA)
Abu-Izneid, Tareq& Rauf, Abdur& Shah, Syed Uzair A.& Wadood, Abdul& Abdelhady, Mohamed I. S.& Priymenko, Nathalie…[et al.]. 2018. In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126171
Modern Language Association (MLA)
Abu-Izneid, Tareq…[et al.]. In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126171
American Medical Association (AMA)
Abu-Izneid, Tareq& Rauf, Abdur& Shah, Syed Uzair A.& Wadood, Abdul& Abdelhady, Mohamed I. S.& Priymenko, Nathalie…[et al.]. In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126171