Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects
Joint Authors
Yildirim, Selin
Ozener, Hafize O.
Köse, Kemal N.
Ozbeyli, Dilek
Soluk-Tekkesin, Merva
Kuru, Leyla
Ağralı, Ömer Birkan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyaluronic acid (HA) constitutes one of the major components of the extracellular matrix domain in almost all mammals.
The aim of this study was to evaluate the regenerative capacity of HA matrix in rat calvarial bone defects and compare with those of different combinations of resorbable collagen membrane (M) and bovine-derived xenograft (G).
Twenty-four 3-month-old male Sprague-Dawley rats weighing 200-250 g were included.
Control group was created by leaving one defect empty from 2 critical size defects with 5 mm diameter formed in the calvarial bones of 8 rats.
In the same rats, the other defect was treated with HA matrix alone.
One of the 2 defects formed in other 8 rats was treated with HA+G and the other with HA+M.
One of the 2 defects formed in the remaining 8 rats was treated with G+M and the other with HA+G+M.
The animals were sacrificed at 4 weeks.
Histologic, histomorphometric, and immunohistochemical analyses were performed.
Both HA matrix alone and its combinations with G and M supported new bone formation (NBF).
However, NBF was significantly greater in G+M and HA+G+M groups compared to control and HA alone (P<0.001).
Bone morphogenetic protein-2 was expressed with varying degrees in all groups, without any difference among them.
Within the limitations of the present study, HA matrix, used alone or in combination with G and M, did not contribute significantly to bone regeneration in rat calvarial bone defects.
American Psychological Association (APA)
Ağralı, Ömer Birkan& Yildirim, Selin& Ozener, Hafize O.& Köse, Kemal N.& Ozbeyli, Dilek& Soluk-Tekkesin, Merva…[et al.]. 2018. Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126184
Modern Language Association (MLA)
Ağralı, Ömer Birkan…[et al.]. Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126184
American Medical Association (AMA)
Ağralı, Ömer Birkan& Yildirim, Selin& Ozener, Hafize O.& Köse, Kemal N.& Ozbeyli, Dilek& Soluk-Tekkesin, Merva…[et al.]. Evaluation of the Effectiveness of Esterified Hyaluronic Acid Fibers on Bone Regeneration in Rat Calvarial Defects. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126184