Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth
Joint Authors
Ju, Yanqin
Huang, Lijuan
Wang, Shuwei
Zhao, Shouliang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Nifedipine-induced gingival overgrowth (NGO) is a multifactorial pathogenesis with increased extracellular matrix including collagen and glycans, inflammatory cytokines, and phenotype changes of fibroblasts.
However, the molecular etiology of NGO is not well understood.
The objective of this study is to investigate the key genes in the pathogenesis of NGO.
Methods.
In this study, we examined the proliferation and migration abilities of fibroblasts derived from patients with chronic periodontitis, nifedipine nonresponder gingival overgrowth, gingival overgrowth caused by nifedipine, and healthy normal gingiva.
We conducted RNA-Seq on these four groups of fibroblasts and analysed the differentially expressed genes (DEGs).
Results.
Fibroblasts derived from NGO patients had higher proliferation and migration abilities than those of the other groups.
Protein-protein interaction network analysis indicated that TGFB2, ITGA8, ITGA11, FGF5, PLA2G4D, PLA2G2F, PTGS1, CSF1, LPAR1, CCL3, and NKX3-1 are involved in the development of NGO.
These factors are related to the arachidonic acid metabolism and PI3K/AKT signaling pathways.
Conclusion.
Transcriptional gene expression analysis identified a number of DEGs that might be functionally related to gingival overgrowth induced by nifedipine.
Our study provides important information on the molecular mechanism underlying nifedipine-induced gingival overgrowth.
American Psychological Association (APA)
Ju, Yanqin& Huang, Lijuan& Wang, Shuwei& Zhao, Shouliang. 2020. Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126185
Modern Language Association (MLA)
Ju, Yanqin…[et al.]. Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth. Analytical Cellular Pathology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1126185
American Medical Association (AMA)
Ju, Yanqin& Huang, Lijuan& Wang, Shuwei& Zhao, Shouliang. Transcriptional Analysis Reveals Key Genes in the Pathogenesis of Nifedipine-Induced Gingival Overgrowth. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1126185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126185