![](/images/graphics-bg.png)
White Ginseng Ameliorates Depressive Behavior and Increases Hippocampal 5-HT Level in the Stressed Ovariectomized Rats
Joint Authors
Shim, Insop
Won, Ran
Lee, Hyun-ju
Jang, Daehyuk
Lee, Kyungjun
Kim, Kyu-Ri
Lee, Seung Eun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Postmenopausal depression is closely associated with depletion of estrogen which modulates transmission of 5-HT, a key neurotransmitter that regulates stress-managing circuits in the brain.
In this study, antidepressive efficacy of white ginseng (Panax gingseng Meyer, WG) was evaluated in stressed ovariectomized rats.
Female Sprague Dawley rats were ovariectomized and repeatedly restraint stressed for 2 weeks (2h/day).
Thirty minutes before restraint stress, rats were administered saline (control), WG 200 mg/kg (p.o.), WG 400 mg/kg (p.o.), or fluoxetine (PC, 10 mg/kg, i.p.).
Tail suspension test (TST) and forced swimming test (FST) were performed to assess antidepressant effect of WG.
After behavioral tests, levels of serum corticosterone (CORT) and hippocampal 5-HT were measured.
Significant decrease of immobility time in TST and FST was shown in rats administered with PC or WG 400 compared to the control.
WG200-treated rats showed remarkable reduction in immobility time of TST.
PC, WG 200, or WG 400-administred group exhibited significant reduction of CORT compared to the control.
PC or WG-treated rats exhibited remarkable increase in hippocampal 5-HT concentration compared to the control.
Hippocampal 5-HT levels in WG groups were higher than those in the PC group.
The present study demonstrated that WG had antidepressant efficacy in an animal model of menopausal depression.
Treatment with WG enhanced hippocampal 5-HT level while suppressing depressive symptom and serum CORT level.
These results provide evidence that WG plays an important role in activating serotonergic neurons in stressful situation, suggesting that WG might be a reliable natural alternative of antidepressant drugs to treat menopausal depression.
American Psychological Association (APA)
Jang, Daehyuk& Lee, Hyun-ju& Lee, Kyungjun& Kim, Kyu-Ri& Won, Ran& Lee, Seung Eun…[et al.]. 2019. White Ginseng Ameliorates Depressive Behavior and Increases Hippocampal 5-HT Level in the Stressed Ovariectomized Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1126187
Modern Language Association (MLA)
Jang, Daehyuk…[et al.]. White Ginseng Ameliorates Depressive Behavior and Increases Hippocampal 5-HT Level in the Stressed Ovariectomized Rats. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1126187
American Medical Association (AMA)
Jang, Daehyuk& Lee, Hyun-ju& Lee, Kyungjun& Kim, Kyu-Ri& Won, Ran& Lee, Seung Eun…[et al.]. White Ginseng Ameliorates Depressive Behavior and Increases Hippocampal 5-HT Level in the Stressed Ovariectomized Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1126187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126187