Expression of Tight Junction Proteins Is Altered in Bladder Cancer
Joint Authors
Chen, Bangbin
Bu, Renge
Xu, Xuewen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bladder cancer (BC) is one of the tumors which occur most frequently in urological system, but less is known about the expression of tight junction proteins and its clinical significance in BC.
In this study, expression of claudin-4, zonula occludens-1 (ZO-1) and zonula occludens-1 nucleic acid-binding protein (ZONAB), in BC tissues, adjacent nontumor tissue (ANTT), and BC cell lines was examined by Western blotting, semiquantitative RT-PCR, and immunohistochemistry, and then, the clinical significance of these proteins was investigated.
The mRNA and protein expression of ZONAB were significantly upregulated, while those of ZO-1 was significantly downregulated in some BC cell lines and tissues in comparison with nontumor urothelial cell lines and ANTT.
High expression rate of ZO-1 and ZONAB had negative correlation in BC tissues and was also correlated with muscle-invasive lesions in BC tissues.
In conclusion, the expression of tight junction proteins is significantly altered in BC and ZO-1, and ZONAB interaction might be involved in BC development.
American Psychological Association (APA)
Chen, Bangbin& Bu, Renge& Xu, Xuewen. 2020. Expression of Tight Junction Proteins Is Altered in Bladder Cancer. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1126188
Modern Language Association (MLA)
Chen, Bangbin…[et al.]. Expression of Tight Junction Proteins Is Altered in Bladder Cancer. Analytical Cellular Pathology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1126188
American Medical Association (AMA)
Chen, Bangbin& Bu, Renge& Xu, Xuewen. Expression of Tight Junction Proteins Is Altered in Bladder Cancer. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1126188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126188