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KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma
Joint Authors
Sun, Yue-Feng
Wu, Hong-Li
Shi, Rui-Fang
Chen, Lin
Meng, Chao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver cancer is thought as the most common human malignancy worldwide, and hepatocellular carcinoma (HCC) accounts for nearly 90% liver cancer.
Due to its poor early diagnosis and limited treatment, HCC has therefore become the most lethal malignant cancers in the world.
Recently, molecular targeted therapies showed great promise in the treatment of HCC, and novel molecular therapeutic targets is urgently needed.
KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division.
Additionally, KIF15 has been reported to participate in the growth of various types of tumors; however, the relation between KIF15 and HCC is unclear.
Herein, our study investigated the possible role of KIF15 on the progression of HCC and found that KIF15 has high expression in tumor samples from HCC patients.
KIF15 could play a critical role in the regulation of cell proliferation of HCC, which was proved by in vitro and in vivo assays.
In conclusion, this study confirmed that KIF15 could be a novel therapeutic target for the treatment of HCC.
American Psychological Association (APA)
Sun, Yue-Feng& Wu, Hong-Li& Shi, Rui-Fang& Chen, Lin& Meng, Chao. 2020. KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126190
Modern Language Association (MLA)
Sun, Yue-Feng…[et al.]. KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma. Analytical Cellular Pathology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1126190
American Medical Association (AMA)
Sun, Yue-Feng& Wu, Hong-Li& Shi, Rui-Fang& Chen, Lin& Meng, Chao. KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1126190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126190