Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality
Joint Authors
Al-Dayan, Noura
Venugopal, Divya
Dhanasekaran, Sugapriya
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The impact of the SARS-CoV-2 pandemic has significantly affected global health and created a world crisis.
The exponentially increasing numbers of infection and mortality have made preventive measures challenging.
India being a highly populated nation has so far effectively counteracted the pandemic outbreak with a significantly lower rate of mortality despite the high infection rates.
The genetic architecture of the immune response genes in the Indian population, BCG vaccination, the predominantly young age group of people, and their traditional food habits might contribute to the lower rate of mortality.
Human leukocyte antigens (HLA) play a vital role in triggering T cells, and natural killer (NK) cells can immediately react to eliminate infected cells.
Activation of virus-specific CD4+ T cells and CD8+ cytotoxic T cells selectively targets the infected cells and strengthens the immunoregulatory system.
The checkpoint for NK cell function is the engagement of killer Ig-like receptors (KIR) molecules with their respective HLA ligands overexpressed or expressed on the compromised virus-infected cells which have shown polymorphism among different ethnic groups.
Here, we explore if certain KIR-HLA motifs grant Indians a survival advantage in terms of the low rate of mortality.
Additionally, enhanced immunity through BCG vaccination may favor fruitful eradication of SARS-CoV-2 and provide the way out as in therapeutic intervention and vaccination strategies.
American Psychological Association (APA)
Al-Dayan, Noura& Venugopal, Divya& Dhanasekaran, Sugapriya. 2020. Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1126192
Modern Language Association (MLA)
Al-Dayan, Noura…[et al.]. Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality. Analytical Cellular Pathology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1126192
American Medical Association (AMA)
Al-Dayan, Noura& Venugopal, Divya& Dhanasekaran, Sugapriya. Footprint of the COVID-19 Pandemic in India: A Study of Immune Landscape and Other Factors Shielding Mortality. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1126192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126192