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Identification of Mitochondrial Ligands with Hepatoprotective Activity from Notopterygii Rhizoma et Radix Using Affinity UltrafiltrationLiquid ChromatographyMass Spectrometry
Joint Authors
Yu, Jie
Gu, Wen
Yang, Xingxin
Liang, Li
Li, Feng-Jiao
Liu, Xin
Mu, Jian-Kang
Wang, Xi
Dong, Jin-Cai
Zeng, Lin-Xi
Li, Jing-Ping
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In recent years, the incidence of diseases associated with hepatic injury has increased in prevalence.
Targeting the mitochondria to protect liver function has gained momentum due to their central role in energy production, apoptotic cell death, oxidative stress, calcium homeostasis, and lipid metabolism.
In this study, we employed a hepatic mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry method (CM-HMC) to identify hepatic mitochondria ligands from medicinal herbs (MHs) including Notopterygii Rhizoma et Radix (NRR) that possess hepatic-protective effects.
A total of 4 newly identified mitochondrial ligands were successfully identified by CM-HMC.
The mitochondria-regulating activities of 3 of the 4 hits were confirmed using isolated mitochondria.
The hepatic-protective effects of one of these hits were validated in carbon tetrachloride-damaged human liver L02 cell models.
We have thus identified new natural hepatic-protectants that enhance our understanding of the hepatic-protective mechanisms of MHs.
CM-HMC was proven to efficiently screen for mitochondrial ligands from MHs.
American Psychological Association (APA)
Liang, Li& Li, Feng-Jiao& Liu, Xin& Mu, Jian-Kang& Wang, Xi& Dong, Jin-Cai…[et al.]. 2019. Identification of Mitochondrial Ligands with Hepatoprotective Activity from Notopterygii Rhizoma et Radix Using Affinity UltrafiltrationLiquid ChromatographyMass Spectrometry. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126201
Modern Language Association (MLA)
Liang, Li…[et al.]. Identification of Mitochondrial Ligands with Hepatoprotective Activity from Notopterygii Rhizoma et Radix Using Affinity UltrafiltrationLiquid ChromatographyMass Spectrometry. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126201
American Medical Association (AMA)
Liang, Li& Li, Feng-Jiao& Liu, Xin& Mu, Jian-Kang& Wang, Xi& Dong, Jin-Cai…[et al.]. Identification of Mitochondrial Ligands with Hepatoprotective Activity from Notopterygii Rhizoma et Radix Using Affinity UltrafiltrationLiquid ChromatographyMass Spectrometry. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126201