PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition
Joint Authors
Zhou, Chengjun
Chen, Yuan
Zhang, Longxiao
Wang, Dehai
Liu, Zhenzhong
Wang, Xiao
Xiao, Hui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Breast cancer is the leading cause of females characterized by high invasive potential.
It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets.
PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue.
PKM2 participates in the cancer-specific Warburg effect to regulate fast glucose intake consumption.
Besides, PKM2 also contributes to cancer progression, especially tumor metastasis.
In this study, we showed that PKM2 is upregulated in breast cancer tissues and the upregulating of PKM2 in breast cancer correlates with poor prognosis.
PKM2 can regulate tumor progression by promoting tumor cell viability and mobility.
Furthermore, overexpression of PKM2 can promote EMT to encourage tumor metastasis.
These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer.
American Psychological Association (APA)
Xiao, Hui& Zhang, Longxiao& Chen, Yuan& Zhou, Chengjun& Wang, Xiao& Wang, Dehai…[et al.]. 2020. PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition. Analytical Cellular Pathology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1126203
Modern Language Association (MLA)
Xiao, Hui…[et al.]. PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition. Analytical Cellular Pathology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1126203
American Medical Association (AMA)
Xiao, Hui& Zhang, Longxiao& Chen, Yuan& Zhou, Chengjun& Wang, Xiao& Wang, Dehai…[et al.]. PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition. Analytical Cellular Pathology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1126203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126203