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Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line
Joint Authors
Feng, Jianguo
Danying, Wan
Ruibin, Jiang
Guoping, Cheng
Zhiguo, Zheng
Maowei, Ni
Linhui, Gu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ovarian cancer leads the worst prognosis among all types of gynecologic malignancies, and patients are often diagnosed at an advanced stage.
Ovarian cancer also has a high rate of metastasis; however, the detailed mechanisms for ovarian cancer prone to metastasis remain unclear.
In this study, we used continuous in vitro screening of the human ovarian cancer A2780 cell line to establish a cell line (A2780-M) which shows high invasiveness and motility.
Compared to the parental cells, A2780-M cells express elevated protein levels of CD44, CD133, CD34, and β-catenin.
A2780-M cells are also more resistant to chemotherapeutic agents SN-38 and Docetaxel.
Thus, the A2780-M cell line is a new ovarian metastatic cancer cell line that expresses tumor stem cell surface markers and adhesion-related membrane proteins and is with higher motility and invasiveness.
American Psychological Association (APA)
Ruibin, Jiang& Guoping, Cheng& Zhiguo, Zheng& Maowei, Ni& Danying, Wan& Feng, Jianguo…[et al.]. 2018. Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126253
Modern Language Association (MLA)
Ruibin, Jiang…[et al.]. Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126253
American Medical Association (AMA)
Ruibin, Jiang& Guoping, Cheng& Zhiguo, Zheng& Maowei, Ni& Danying, Wan& Feng, Jianguo…[et al.]. Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126253