The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients
Joint Authors
Chaia-Semerena, Genny Margarita
Vargas-Camaño, María Eugenia
Alonso-Bello, Cesar Daniel
Guillén-Toledo, Jorge Javier
Guido-Bayardo, Ricardo Leopoldo
Lozano-Patiño, Fernando
Temix-Delfín, Mariano Daniel
Castrejón-Vázquez, María Isabel
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients.
For this reason, the current recommendation for the use of these medications is in a short cycle to avoid adverse effects when used frequently and for prolonged periods of time.
Objectives.
To learn variations in serum levels of autoantibodies in autoimmune diseases treated with steroids on alternate days, as well as whether there are differences in the response to them depending on the type of disease.
Study Design.
A descriptive, retrospective, and cross-sectional study was conducted in which serum autoantibody levels were compared at the time of diagnosis and three months after alternate-day corticosteroid therapy.
Results.
We included 106 patients from three autoimmune connective tissue diseases (systemic lupus erythematosus, Sjögren syndrome, and Hashimoto’s thyroiditis) and observed a statistically significant decrease in serum autoantibody levels both in patients with lupus and those with Hashimoto’s thyroiditis, regardless of the sex of the patients, as well as the type of steroids used.
Conclusions.
Treatment with alternate-day corticosteroids achieved a statistically significant decrease in serum autoantibody levels in patients with systemic lupus erythematosus and Hashimoto’s thyroiditis.
American Psychological Association (APA)
Chaia-Semerena, Genny Margarita& Vargas-Camaño, María Eugenia& Alonso-Bello, Cesar Daniel& Guillén-Toledo, Jorge Javier& Guido-Bayardo, Ricardo Leopoldo& Lozano-Patiño, Fernando…[et al.]. 2020. The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients. Autoimmune Diseases،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126254
Modern Language Association (MLA)
Chaia-Semerena, Genny Margarita…[et al.]. The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients. Autoimmune Diseases No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1126254
American Medical Association (AMA)
Chaia-Semerena, Genny Margarita& Vargas-Camaño, María Eugenia& Alonso-Bello, Cesar Daniel& Guillén-Toledo, Jorge Javier& Guido-Bayardo, Ricardo Leopoldo& Lozano-Patiño, Fernando…[et al.]. The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients. Autoimmune Diseases. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126254