Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Abstract EN

Introduction.

The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial.

We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients.

Methods.

We performed a longitudinal cohort study.

Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer.

Results.

We consecutively recruited ten patients diagnosed with BRONJ in stage I or II.

These patients underwent a surgical laser-assisted therapy together with autologous PRP.

At the latest follow-up at 12 months, clinical improvement was observed in eight patients.

Registration Number is IRCT20180329039159N1.

Conclusion.

We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients’ lesions clinically.

Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.