The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
Joint Authors
Zhang, Ying
Lin, Yong
Liu, Qing
Yuan, Xuemei
Mao, Anqiong
Liu, Yuexin
Li, Qun
Zheng, Jie
Hu, Bin
Yu, Fengxu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD.
However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expression in hippocampus and prefrontal cortex cerebrospinal fluid after extracorporeal circulation operation in aged rats.
We Found that, compared with POCD group, the cognitive function was improved in POCD + Dex group.
We speculate that dexmedetomidine could improve the cognitive function after extracorporeal circulation operation in aged rats and Aβ, p-Tau, and PSD95 protein might have contributed to this favorable outcome.
American Psychological Association (APA)
Zhang, Ying& Lin, Yong& Liu, Qing& Yuan, Xuemei& Mao, Anqiong& Liu, Yuexin…[et al.]. 2018. The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126268
Modern Language Association (MLA)
Zhang, Ying…[et al.]. The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126268
American Medical Association (AMA)
Zhang, Ying& Lin, Yong& Liu, Qing& Yuan, Xuemei& Mao, Anqiong& Liu, Yuexin…[et al.]. The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126268
