URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion
Joint Authors
Pan, Bin
Ye, Yunlin
Liu, Haiping
Zhen, Jianli
Zhou, Hongmei
Li, Yutong
Qu, Lijun
Wu, Youke
Zeng, Chuanrong
Zhong, Weifeng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers.
However, the role of URG11 in prostate cancer remains yet to be elucidated.
By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues.
Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lines (DU145, PC3, and LNCaP), compared with human prostate epithelial cell line (RWPE-1).
Moreover, by the application of siRNA against URG11, the proliferation, migration, and invasion of prostate cancer cells were markedly inhibited.
Genetic knockdown of URG11 also induced cell cycle arrest at G1/S phase, induced apoptosis, and decreased the expression level of β-catenin in prostate cancer cells.
Overexpression of URG11 promoted the expression of β-catenin, the growth, the migration, and invasion ability of prostate cancer cells.
Taken together, this study reveals that URG11 is critical for the proliferation, migration, and invasion in prostate cancer cells, providing the evidence of URG11 to be a novel potential therapeutic target of prostate cancer.
American Psychological Association (APA)
Pan, Bin& Ye, Yunlin& Liu, Haiping& Zhen, Jianli& Zhou, Hongmei& Li, Yutong…[et al.]. 2018. URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126313
Modern Language Association (MLA)
Pan, Bin…[et al.]. URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126313
American Medical Association (AMA)
Pan, Bin& Ye, Yunlin& Liu, Haiping& Zhen, Jianli& Zhou, Hongmei& Li, Yutong…[et al.]. URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126313