Preclinical Modeling of DCD Class III Donation: Paving the Way for the Increased Use of This Challenging Donor Type
Joint Authors
Hauet, T.
Soussi, David
Rod, Xavier
Thuillier, Raphael
Leblanc, Suzanne
Goujon, Jean-Michel
Barrou, Benoit
Kerforne, Thomas
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deceased after circulatory death (DCD) donors offer a viable solution to the current organ shortage, particularly the Maastricht Class III (arrest subsequent to cessation of life support in the hospital).
Although current results from these donors are very satisfactory, the number of included donors is too low and future expansion of inclusion criteria will likely decrease organ quality, with negative consequences on the complication rate.
This donor type thus represents a priority in terms of scientific exploration, so as to study it in controlled settings and prepare for future challenges.
Hence, we mimicked the DCD Class III clinical conditions a Large White pig model.
Herein, we detail the different strategies attempted to attain our objectives, including technical approaches such as animal positioning and ventilator settings, as well as pharmacological intervention to modulate blood pressure and heart rate.
We highlight the best combination of factors to successfully reproduce DCD Class III conditions, with perfusion pressures and functional warm ischemia (hypoperfusion) closely resembling clinical situations.
Finally, we detail the functional and histological impacts of these conditions.
Such a model could be of critical value to explore novel management alternative for these donors, presenting a uniquely adapted platform for such therapeutics as normothermic regional circulation and/or pharmacological intervention.
American Psychological Association (APA)
Soussi, David& Rod, Xavier& Thuillier, Raphael& Leblanc, Suzanne& Goujon, Jean-Michel& Barrou, Benoit…[et al.]. 2019. Preclinical Modeling of DCD Class III Donation: Paving the Way for the Increased Use of This Challenging Donor Type. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126329
Modern Language Association (MLA)
Soussi, David…[et al.]. Preclinical Modeling of DCD Class III Donation: Paving the Way for the Increased Use of This Challenging Donor Type. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126329
American Medical Association (AMA)
Soussi, David& Rod, Xavier& Thuillier, Raphael& Leblanc, Suzanne& Goujon, Jean-Michel& Barrou, Benoit…[et al.]. Preclinical Modeling of DCD Class III Donation: Paving the Way for the Increased Use of This Challenging Donor Type. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126329