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MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells
Joint Authors
Fan, Zhenwei
Wang, Xuan
Zhang, Min
Zhao, Chunshan
Mei, Chunli
Li, Peng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Oxidative stress due to reactive oxygen species plays a central role in pathophysiology of neurodegenerative diseases.
Inhibition of mitogen-activated protein kinase (MAPK) cascades attenuates the oxidative induced cell stress and behaves as potential neuroprotection agent.
Materials and Methods.
In this study, we evaluate hydrogen peroxide induced neural cell stress and determine how different MAPK inhibitors restore the cell damage.
Results.
The results indicated that oxidative stress induced by neural cell damage commonly exists, and MAPK inhibitors partially and selectively attenuated the cell damage by reducing ROS production and cell apoptosis.
The cultured neurons are more susceptible to hydrogen peroxide than subculture cells.
Conclusion.
We conclude that the essential role of different MAPK inhibitors is to attenuate the hydrogen peroxide induced neuronal cell damage.
Those data broaden the implication between individual neural cells and different MAPK inhibitors and give clues for oxidative stress induced neural diseases.
American Psychological Association (APA)
Fan, Zhenwei& Wang, Xuan& Zhang, Min& Zhao, Chunshan& Mei, Chunli& Li, Peng. 2019. MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126361
Modern Language Association (MLA)
Fan, Zhenwei…[et al.]. MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126361
American Medical Association (AMA)
Fan, Zhenwei& Wang, Xuan& Zhang, Min& Zhao, Chunshan& Mei, Chunli& Li, Peng. MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126361