Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep
Joint Authors
Błaszczyk, Bartłomiej
Kaspera, Wojciech
Ficek, Krzysztof
Kajor, Maciej
Binkowski, Marcin
Stodolak-Zych, Ewa
Grajoszek, Aniela
Bursig, Henryk
Ładziński, Piotr
Stojko, Jerzy
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study was to verify whether L-lactide/DL-lactide copolymer 80/20 (PLDLLA) and platelet-rich plasma (PRP) trigger bone formation within critical-sized calvarial defects in adult sheep ( n = 6 ).
Two craniectomies, each ca.
3 cm in diameter, were created in each animal.
The first craniectomy was protected with an inner polylactide membrane, filled with PRP-polylactide granules, and covered with outer polylactide membrane.
The second control craniectomy was left untreated.
The animals were euthanized at 6, 7, 17, 19, 33, and 34 weeks after surgery, and the quality and the rate of reossification were assessed histomorphometrically and microtomographically.
The study demonstrated that application of implants made of PLDLLA 80/20 combined with an osteopromotive substance (e.g., PRP) may promote bone healing in large calvarial defect in sheep.
These promising proof-of-concept studies need to be verified in the future on a larger cohort of animals and over a longer period of time in order to draw definitive conclusions.
American Psychological Association (APA)
Błaszczyk, Bartłomiej& Kaspera, Wojciech& Ficek, Krzysztof& Kajor, Maciej& Binkowski, Marcin& Stodolak-Zych, Ewa…[et al.]. 2018. Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126380
Modern Language Association (MLA)
Błaszczyk, Bartłomiej…[et al.]. Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1126380
American Medical Association (AMA)
Błaszczyk, Bartłomiej& Kaspera, Wojciech& Ficek, Krzysztof& Kajor, Maciej& Binkowski, Marcin& Stodolak-Zych, Ewa…[et al.]. Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126380