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The Effect of 5-Hydroxytryptamine Receptor Antagonist in Preventing PainLimb Shrinkage Reaction Associated with Rocuronium Injection
Joint Authors
Zhou, Chengmao
Zhu, Yu
He, Qixiong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To evaluate the effect and safety of 5-hydroxytryptamine (5-HT) receptor antagonist in alleviating the pain of patients under general anesthesia induced by rocuronium injection and preemptive analgesia.
Methods.
Meta-analysis was conducted with RevMan 5.1 software by electronically retrieving the databases of PubMed, Embase, the Cochrane Library, WanFang Data, and CNKI and collecting the published random control tests (RCTs) where 5-hydroxytryptamine receptor antagonist was used to alleviate the pain/limb shrinkage reaction associated with rocuronium injection.
Results.
Seven RTCs, including 556 patients, were included.
The results of meta-analysis showed the following.
(1) Compared to the control group, 5-HT receptor antagonist could prevent the total pain/limb shrinkage reaction associated with rocuronium injection [RR=0.62, 95% CI (0.54, 0.71), P<0.00001] and reduce the incidence rate of mild and moderate pain/limb shrinkage reaction associated with rocuronium injection [RR=0.46, 95% CI (0.33, 0.63), P<0.00001; RR=0.18, 95% CI (0.11, 0.31), P<0.000 01].
(2) Compared to the lidocaine group, the incidence rate was higher in preventing the pain/limb shrinkage reaction associated with rocuronium injection by 5-HT receptor antagonist, which was statistically significant [RR=1.33, 95% CI (1.05, 1.68), P=0.02].
Conclusion.
5-hydroxytryptamine receptor antagonist may be effective in preventing the pain/limb shrinkage reaction associated with rocuronium injection.
American Psychological Association (APA)
He, Qixiong& Zhou, Chengmao& Zhu, Yu. 2018. The Effect of 5-Hydroxytryptamine Receptor Antagonist in Preventing PainLimb Shrinkage Reaction Associated with Rocuronium Injection. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126387
Modern Language Association (MLA)
He, Qixiong…[et al.]. The Effect of 5-Hydroxytryptamine Receptor Antagonist in Preventing PainLimb Shrinkage Reaction Associated with Rocuronium Injection. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1126387
American Medical Association (AMA)
He, Qixiong& Zhou, Chengmao& Zhu, Yu. The Effect of 5-Hydroxytryptamine Receptor Antagonist in Preventing PainLimb Shrinkage Reaction Associated with Rocuronium Injection. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1126387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126387