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Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux
Joint Authors
Wang, Lili
Dong, Quanjiang
Zhou, Jianhua
Gao, Xiaoli
Huang, Shengyun
Ma, Li
Cui, Yanjun
Wang, Hengkun
Qiu, Jianzhong
Chen, Zhenggang
Wang, Xuxia
Zhang, Dongsheng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The objective of this study is to evaluate the effect of simvastatin on the jaw bone microstructural defect and autophagy in rats with high cholesterol diet (HCD).
Methods.
Male Sprague-Dawley rats were fed a standard rodent chow (NC group) or a high cholesterol diet for 32 weeks and the HCD-fed rats were treated with vehicle (HC group) or simvastatin (5 mg/kg orally daily for 8 weeks, HC + SIM group, and n = 10 /group).
The static histomorphometric changes in the jaw bone tissues in individual rats were evaluated.
The relative levels of OPG, RANKL, NF-κB, LC3, and p62 in the jaw bone tissues were determined by quantitative RT-PCR and/or immunohistochemistry.
Results.
Compared with the NC group, the HC groups had lower trabecular bone volume, trabecular thickness and trabecular number, and increased ratios of RANKL/OPG in the jaw bone, accompanied by enhanced NF-κB activation and autophagy.
Simvastatin treatment inhabited these changes, including the decreased levels of serum proinflammatory cytokines and increased autophagy.
Conclusion.
Simvastatin treatment could inhibit the hyperlipidemia-induced jaw bone microstructural defect in rats by increasing autophagic flux.
American Psychological Association (APA)
Zhou, Jianhua& Gao, Xiaoli& Huang, Shengyun& Ma, Li& Cui, Yanjun& Wang, Hengkun…[et al.]. 2018. Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126399
Modern Language Association (MLA)
Zhou, Jianhua…[et al.]. Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126399
American Medical Association (AMA)
Zhou, Jianhua& Gao, Xiaoli& Huang, Shengyun& Ma, Li& Cui, Yanjun& Wang, Hengkun…[et al.]. Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126399