A Model to Predict In-Hospital Mortality in HIVAIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World
Joint Authors
Wu, Liang
Zhang, Zhe
Wang, Yu
Hao, Yiwei
Wang, Fang
Gao, Guiju
Yang, Di
Xiao, Jiang
Zhao, Hongxin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aimed to develop and validate a predictive model to evaluate in-hospital mortality risk in HIV/AIDS patients with PCP in China.
1001 HIV/AIDS patients with PCP admitted in the Beijing Ditan hospital from August 2009 to January 2018 were included in this study.
Multivariate Cox proportional hazard model was used to identify independent risk factors of death, and a predictive model was devised based on risk factors.
The overall in-hospital mortality was 17.3%.
The patients were randomly assigned into derivation cohort (801cases) and validation cohort (200 cases) in 8:2 ratio, respectively, in which in derivation cohort we found that 7 predictors, including LDH >350U/L, HR>130 times/min, room air PaO2 <70mmHg, later admission to ICU, Anemia (HGB≤90g/L), CD4<50cells/ul, and development of a pneumothorax, were associated with poor prognosis in HIV/AIDS patients with PCP and were included in the predictive model.
The model had excellent discrimination with AUC of 0.904 and 0.921 in derivation and validation cohort, respectively.
The predicted scores were divided into two groups to assess the in-hospital mortality risk: low-risk group (0-11 points with mortality with 2.15-12.77%) and high-risk group (12-21 points with mortality with 38.78%-81.63%).
The cumulative mortality rate also indicated significant difference between two groups with Kaplan-Meier curve (p<0.001).
A predictive model to evaluate mortality in HIV/AIDS patients with PCP was constructed based on routine laboratory and clinical parameters, which may be a simple tool for physicians to assess the prognosis in HIV/AIDS patients with PCP in China.
American Psychological Association (APA)
Wu, Liang& Zhang, Zhe& Wang, Yu& Hao, Yiwei& Wang, Fang& Gao, Guiju…[et al.]. 2019. A Model to Predict In-Hospital Mortality in HIVAIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126414
Modern Language Association (MLA)
Wu, Liang…[et al.]. A Model to Predict In-Hospital Mortality in HIVAIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1126414
American Medical Association (AMA)
Wu, Liang& Zhang, Zhe& Wang, Yu& Hao, Yiwei& Wang, Fang& Gao, Guiju…[et al.]. A Model to Predict In-Hospital Mortality in HIVAIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126414