Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola
Joint Authors
Turck, Natacha
Bonnet, Julien
Courtioux, Bertrand
Vignoles, Philippe
Tiberti, Natalia
Gedeão, Vatunga
Hainard, Alexandre
Josenando, Theophile
Ndung’u, Joseph M
Sanchez, Jean-Charles
Bisser, Sylvie
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human African Trypanosomiasis may become manageable in the next decade with fexinidazole.
However, currently stage diagnosis remains difficult to implement in the field and requires a lumbar puncture.
Our study of an Angolan cohort of T.
b.
gambiense-infected patients used other staging criteria than those recommended by the WHO.
We compared WHO criteria (cell count and parasite identification in the CSF) with two biomarkers (neopterin and CXCL-13) which have proven potential to diagnose disease stage or relapse.
Biological, clinical, and neurological data were analysed from a cohort of 83 patients.
A neopterin concentration below 15.5 nmol/L in the CSF denoted patients with stage 1 disease, and a concentration above 60.31 nmol/L characterized patients with advanced stage 2 (trypanosomes in CSF and/or cytorachia higher than 20 cells) disease.
CXCL-13 levels below 91.208 pg/mL denoted patients with stage 1 disease, and levels of CXCL-13 above 395.45 pg/mL denoted patients with advanced stage 2 disease.
Values between these cut-offs may represent patients with intermediate stage disease.
Our work supports the existence of an intermediate stage in HAT, and CXCL-13 and neopterin levels may help to characterize it.
American Psychological Association (APA)
Bonnet, Julien& Vignoles, Philippe& Tiberti, Natalia& Gedeão, Vatunga& Hainard, Alexandre& Turck, Natacha…[et al.]. 2019. Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126427
Modern Language Association (MLA)
Bonnet, Julien…[et al.]. Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126427
American Medical Association (AMA)
Bonnet, Julien& Vignoles, Philippe& Tiberti, Natalia& Gedeão, Vatunga& Hainard, Alexandre& Turck, Natacha…[et al.]. Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126427