Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
Joint Authors
Vemuri, Ravichandra
Gundamaraju, Rohit
Shastri, Madhur D.
Shukla, Shakti Dhar
Kalpurath, Krishnakumar
Ball, Madeleine
Tristram, Stephen
Shankar, Esaki M.
Ahuja, Kiran
Eri, Rajaraman
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host.
A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system.
With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses.
Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora.
Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem.
This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics.
In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored.
The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing.
The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state.
American Psychological Association (APA)
Vemuri, Ravichandra& Gundamaraju, Rohit& Shastri, Madhur D.& Shukla, Shakti Dhar& Kalpurath, Krishnakumar& Ball, Madeleine…[et al.]. 2018. Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126432
Modern Language Association (MLA)
Vemuri, Ravichandra…[et al.]. Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126432
American Medical Association (AMA)
Vemuri, Ravichandra& Gundamaraju, Rohit& Shastri, Madhur D.& Shukla, Shakti Dhar& Kalpurath, Krishnakumar& Ball, Madeleine…[et al.]. Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126432