Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions
Joint Authors
Luplertlop, Natthanej
Ampawong, Sumate
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cerebral involvement especially brain abscess is life-threatening complication and major cause of death during Scedosporium apiospermum infection.
However, little is known about pathogenesis of brain oedema associated with abscess in scedosporiosis.
Experimental scedosporiosis was conducted in BALB/cMlac mice to characterize the presence of brain oedema, its type, and its related mechanisms focusing on aquaporin (AQP)-4, nuclear factor erythroid-2 related factor (Nrf-2), and tumor necrotic factor (TNF)-α.
The results revealed that S.
apiospermum infection induced severe inflammatory environment relevant to TNF-α expression and cytogenic oedema-associated brain abscess predominately in cerebrum of immunocompromised mice without voriconazole treatment reflecting to downregulation of AQP-4 in neighboring abscess areas and oedematous blood vessels.
Downregulation of Nrf-2 in neuronal cells and myelin degeneration were significantly observed in nontreated mice.
In summary, oxidative stress, severe inflammatory response, and space-occupying mass from abscess formation inducing tissue hypoxia might be the postulate causes of oedema induced by scedosporiosis.
American Psychological Association (APA)
Ampawong, Sumate& Luplertlop, Natthanej. 2019. Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126440
Modern Language Association (MLA)
Ampawong, Sumate& Luplertlop, Natthanej. Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1126440
American Medical Association (AMA)
Ampawong, Sumate& Luplertlop, Natthanej. Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1126440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126440